Sensitizing HRAS overexpressing head and neck squamous cell carcinoma (HNSCC) to chemotherapy

MicroRNAs in Head and Neck Squamous Cell Carcinoma (HNSCC) and Oral Squamous Cell Carcinoma (OSCC)

MicroRNAs (miRNAs) are small, noncoding RNAs which regulate cell differentiation, proliferation, development, cell cycle, and apoptosis. Expression profiling of miRNAs has been performed and the data show that some miRNAs are upregulated or downregulated in cancer. Several studies suggest that the expression profiles of miRNAs are associated with clinical outcomes. However, the set of miRNAs wi...

Abbreviations: HPV: Human Papillomavirus; TSCC: Tonsillar Squamous Cell Carcinoma; HNSCC: Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) encompasses a multitude of cancer types, arising from the mucosal lining of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. Alcohol and tobacco are well-recognized pre-disposing factors for these cancers. Several Nordic countries (Denmark [1], Sweden [2][3], Finland [4]), the United States [5-8] and Australia [9],...

Overcoming Resistance to EGFR inhibitor in Head and Neck Squamous Cell Carcinoma (HNSCC)

Detection of Circulating Tumor Cell Subpopulations in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)

BACKGROUND Since image based diagnostic tools fail to detect early metastasis in head and neck squamous cell carcinoma (HNSCC) it is crucial to develop minimal invasive diagnostic methods. A promising approach is to identify and characterize circulating tumor cells (CTC) in the peripheral blood of HNSCC patients. In this pilot study, we assessed which non-hematopoietic cell types are identifiab...

Epithelial-Mesenchymal Transition and Inflammation in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...